RHBDL3

Across TCGA cell cohorts, RHBDL3 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,931 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RHBDL3-associated GO terms across cancer lineages are Heterochromatin formation, Epigenetic regulation of gene expression, and Heterochromatin organization. Each is linked with RHBDL3 in more than 13 cancer types. Because this analysis shows association rather than direction, both RHBDL3-to-partner and partner-to-RHBDL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heterochromatin formation grouped by RHBDL3-low versus RHBDL3-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RHBDL3→partner) and Y-score (partner→RHBDL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Heterochromatin formation →	+0.042	+0.290	<.001	.005	3	13
BONE	Epigenetic regulation of gene expression →	+0.080	+1.132	.002	.007	2	14
BONE	Heterochromatin organization →	+0.072	+1.134	.009	.008	2	14
UPPER_AERODIGESTIVE_TRACT	DNA-templated transcription initiation →	+0.078	+0.417	<.001	.009	3	13
UPPER_AERODIGESTIVE_TRACT	Transcription initiation at RNA polymerase II promoter →	+0.084	+0.533	<.001	.001	3	13
OESOPHAGUS	Regulation of nucleotide-excision repair →	+0.129	+0.780	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,931 associations by consensus.

Heterochromatin formation by RHBDL3 expression — LARGE_INTESTINE

Explore this box plot interactively →