RHBDL3

Across TCGA cell cohorts, RHBDL3 mutation is significantly associated with the RNA expression of many other genes, with 37 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RHBDL3-associated genes across cancer lineages are ASPN, MAGEB4, and FAM153B. Each is linked with RHBDL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both RHBDL3-to-partner and partner-to-RHBDL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASPN grouped by RHBDL3-low versus RHBDL3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RHBDL3→partner) and Y-score (partner→RHBDL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ASPN →	+0.044	+2.648	<.001	.008	3	1
LARGE_INTESTINE	MAGEB4 →	+0.011	+3.415	<.001	.001	3	1
LARGE_INTESTINE	FAM153B →	+0.384	+3.841	.002	<.001	3	1
LARGE_INTESTINE	MINAR2 →	+0.024	+2.560	.006	.008	3	1
LARGE_INTESTINE	RNF133 →	+0.370	+3.215	<.001	.009	3	1
LARGE_INTESTINE	DAZ2 →	+0.113	+3.415	.008	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

ASPN by RHBDL3 expression — LARGE_INTESTINE

Explore this box plot interactively →