RHBDL2

Across TCGA patient cohorts, RHBDL2 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RHBDL2-associated genes across cancer lineages are Caspase-7-cleavedD198, 14-3-3_beta, and A-Raf_pS299. Each is linked with RHBDL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RHBDL2-to-partner and partner-to-RHBDL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by RHBDL2-low versus RHBDL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RHBDL2→partner) and Y-score (partner→RHBDL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.966	+2.479	<.001	.010	3	2
UCEC	14-3-3_beta →	-0.111	-2.432	.011	.018	3	1
UCEC	A-Raf_pS299 →	-0.118	-2.321	.023	.034	3	1
UCEC	MEK1 →	+0.449	+3.584	.004	.002	3	1
UCEC	MSH2 →	-0.336	-3.143	<.001	.018	3	1
UCEC	Notch1 →	+0.153	+3.013	.012	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Caspase-7-cleavedD198 by RHBDL2 expression — UCEC

Explore this box plot interactively →