RHBDL2

Across TCGA cell cohorts, RHBDL2 protein abundance is significantly associated with the go_rna of many other GO terms, with 1,887 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RHBDL2-associated GO terms across cancer lineages are Positive regulation of cell cycle checkpoint, Regulation of membrane hyperpolarization, and Ventral midline development. Each is linked with RHBDL2 in more than 4 cancer types. Because this analysis shows association rather than direction, both RHBDL2-to-partner and partner-to-RHBDL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of cell cycle checkpoint grouped by RHBDL2-low versus RHBDL2-high in LUNG_NSCLC_LUAD.

protein abundance associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RHBDL2→partner) and Y-score (partner→RHBDL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Positive regulation of cell cycle checkpoint →	+0.075	+0.562	.003	<.001	3	5
SKIN	Regulation of membrane hyperpolarization →	+0.230	+0.421	.004	.002	3	5
PANCREAS	Ventral midline development →	+0.984	+0.555	.002	<.001	3	4
BONE	Microglial cell activation →	-0.203	-0.515	<.001	.002	3	4
BONE	Leukocyte activation involved in inflammatory response →	-0.203	-0.515	<.001	.002	3	4
CNS	Host-mediated perturbation of symbiont process →	+0.052	+0.368	.002	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,887 associations by consensus.

Positive regulation of cell cycle checkpoint by RHBDL2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →