RHBDF2

Across TCGA patient cohorts, RHBDF2 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RHBDF2-associated genes across cancer lineages are FOXO3a, MEK1, and GAPDH. Each is linked with RHBDF2 in more than 2 cancer types. Because this analysis shows association rather than direction, both RHBDF2-to-partner and partner-to-RHBDF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a grouped by RHBDF2-low versus RHBDF2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RHBDF2→partner) and Y-score (partner→RHBDF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	FOXO3a →	-0.163	-3.169	.006	.018	3	2
UCEC	MEK1 →	+0.448	+2.115	.005	.019	3	2
SKCM	GAPDH →	+0.719	+3.321	.018	.010	1	3
UCEC	EGFR_pY1068 →	-0.284	-3.459	.009	.005	3	1
UCEC	ERK2 →	+0.220	+2.115	.008	.019	3	1
UCEC	JNK2 →	+0.360	+2.179	<.001	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

FOXO3a by RHBDF2 expression — SKCM

Explore this box plot interactively →