RHBDF1

Across TCGA patient cohorts, RHBDF1 mutation is significantly associated with the RNA expression of many other genes, with 4,924 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RHBDF1-associated genes across cancer lineages are UHRF1, DHFR, and SEC22B. Each is linked with RHBDF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both RHBDF1-to-partner and partner-to-RHBDF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UHRF1 grouped by RHBDF1-low versus RHBDF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RHBDF1→partner) and Y-score (partner→RHBDF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UHRF1 →	+1.033	+3.818	<.001	<.001	3	3
UCEC	DHFR →	+0.875	+2.700	<.001	<.001	3	3
UCEC	SEC22B →	+0.411	+2.436	.001	.001	3	3
UCEC	CIRBP-AS1 →	+0.653	+2.616	<.001	<.001	3	3
UCEC	TMEM33 →	+0.593	+2.010	<.001	<.001	3	3
STAD	NARS1 →	+0.595	+3.476	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,924 associations by consensus.

UHRF1 by RHBDF1 expression — UCEC

Explore this box plot interactively →