RHBDD3

Across TCGA patient cohorts, RHBDD3 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RHBDD3-associated genes across cancer lineages are ERK2, Di-Ras3, and Heregulin. Each is linked with RHBDD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both RHBDD3-to-partner and partner-to-RHBDD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by RHBDD3-low versus RHBDD3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RHBDD3→partner) and Y-score (partner→RHBDD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.255	+3.000	.008	.036	3	2
UCEC	Di-Ras3 →	-0.232	-2.321	.001	.035	3	2
UCEC	Heregulin →	-0.181	-2.321	.003	.035	3	1
UCEC	MSH6 →	-0.457	-2.321	.005	.035	3	1
UCEC	NF2 →	+0.369	+3.169	<.001	.019	3	1
UCEC	p27_pT157 →	-0.092	-3.459	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

ERK2 by RHBDD3 expression — UCEC

Explore this box plot interactively →