RHAG

Across TCGA patient cohorts, RHAG mutation is significantly associated with the RNA expression of many other genes, with 2,422 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RHAG-associated genes across cancer lineages are SLC3A2, PPP6C, and BORA. Each is linked with RHAG in more than 2 cancer types. Because this analysis shows association rather than direction, both RHAG-to-partner and partner-to-RHAG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC3A2 grouped by RHAG-low versus RHAG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RHAG→partner) and Y-score (partner→RHAG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SLC3A2 →	+0.633	+3.470	<.001	.002	3	3
UCEC	PPP6C →	+0.504	+2.545	<.001	.001	3	3
UCEC	BORA →	+0.679	+3.743	<.001	<.001	3	3
UCEC	MFSD14C →	+0.656	+2.534	<.001	.001	3	3
UCEC	MZT1 →	+0.757	+3.708	.001	<.001	3	3
LGG	PCYT1B-AS1 →	+0.237	+4.272	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,422 associations by consensus.

SLC3A2 by RHAG expression — UCEC

Explore this box plot interactively →