RHAG

Across TCGA patient cohorts, RHAG mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RHAG-associated genes across cancer lineages are PEA-15, EGFR_pY1173, and ER-alpha_pS118. Each is linked with RHAG in more than 1 cancer types. Because this analysis shows association rather than direction, both RHAG-to-partner and partner-to-RHAG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PEA-15 grouped by RHAG-low versus RHAG-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RHAG→partner) and Y-score (partner→RHAG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	PEA-15 →	+0.264	+2.816	.043	.036	3	2
LUSC	EGFR_pY1173 →	+0.324	+2.853	<.001	.034	3	1
LUSC	ER-alpha_pS118 →	+0.161	+2.853	.002	.034	3	1
UCEC	Gab2 →	+0.378	+2.222	.012	.011	3	1
UCEC	HER3 →	-0.272	-2.311	.019	.034	3	1
UCEC	JNK2 →	+0.172	+3.026	.041	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

PEA-15 by RHAG expression — LUSC

Explore this box plot interactively →