RHAG

Across TCGA cell cohorts, RHAG mutation is significantly associated with the RNA expression of many other genes, with 100 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RHAG-associated genes across cancer lineages are MBD3L5, GPR42, and TGM6. Each is linked with RHAG in more than 1 cancer types. Because this analysis shows association rather than direction, both RHAG-to-partner and partner-to-RHAG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MBD3L5 grouped by RHAG-low versus RHAG-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RHAG→partner) and Y-score (partner→RHAG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MBD3L5 →	+0.029	+5.415	<.001	.004	3	1
LUNG_NSCLC_LUAD	GPR42 →	+0.016	+4.887	<.001	.009	3	1
BLOOD_Leukemia	TGM6 →	+0.030	+6.569	<.001	<.001	3	1
BLOOD_Leukemia	ODF4 →	+0.050	+4.922	<.001	.009	3	1
BLOOD_Leukemia	CTXN3 →	+0.012	+5.201	<.001	.006	3	1
CNS	OR6C3 →	+0.035	+5.321	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 100 associations by consensus.

MBD3L5 by RHAG expression — SKIN

Explore this box plot interactively →