RGS9

Across TCGA cell cohorts, RGS9 mutation is significantly associated with the mutation status of many other genes, with 2,146 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RGS9-associated genes across cancer lineages are SLC45A2, LARP4B, and CDH19. Each is linked with RGS9 in more than 3 cancer types. Because this analysis shows association rather than direction, both RGS9-to-partner and partner-to-RGS9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC45A2 grouped by RGS9-low versus RGS9-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGS9→partner) and Y-score (partner→RGS9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SLC45A2 →	+4.560	+4.309	.007	.007	1	4
SKIN	LARP4B →	+4.239	+5.053	.007	.007	1	3
SKIN	CDH19 →	+4.824	+5.392	.004	.004	1	3
SKIN	AFF4 →	+4.239	+5.053	.007	.007	1	3
LARGE_INTESTINE	RIPOR3 →	+2.874	+3.632	.002	.002	1	3
BLOOD_Lymphoma	NOP2 →	+5.584	+5.014	.003	.003	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,146 associations by consensus.

SLC45A2 by RGS9 expression — BLOOD_Leukemia

Explore this box plot interactively →