Across TCGA patient cohorts, RGS6 protein abundance is significantly associated with the RNA expression of many other genes, with 3,605 significant associations in total. GBM shows the largest number of these associations.

The most reproducible RGS6-associated genes across cancer lineages are TSPAN7, PPP2R2B, and DNAJC5G. Each is linked with RGS6 in more than 1 cancer types. Because this analysis shows association rather than direction, both RGS6-to-partner and partner-to-RGS6 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGS6→partner) and Y-score (partner→RGS6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TSPAN7 →	+2.005	+0.793	<.001	.004	3	2
LSCC	PPP2R2B →	+0.939	+1.109	.002	.003	3	2
GBM	DNAJC5G →	+0.353	+0.622	.002	<.001	3	2
LSCC	JAKMIP2 →	+2.001	+1.068	<.001	.005	3	2
LSCC	SLC35F3 →	+1.928	+1.135	<.001	.002	3	2
GBM	VWA7 →	+0.588	+0.489	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,605 associations by consensus.

Exploration

RGS6 survival (RNA) · tumor vs normal (RNA) · all RGS6 data types