Across TCGA patient cohorts, RGS6 mutation is significantly associated with the RNA expression of many other genes, with 2,904 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RGS6-associated genes across cancer lineages are ME3, NTAN1, and DPP9. Each is linked with RGS6 in more than 2 cancer types. Because this analysis shows association rather than direction, both RGS6-to-partner and partner-to-RGS6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGS6→partner) and Y-score (partner→RGS6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ME3 →	-0.698	-2.137	<.001	<.001	3	3
UCEC	NTAN1 →	+0.391	+1.486	<.001	.003	3	3
UCEC	DPP9 →	+0.361	+2.401	<.001	<.001	3	3
SKCM	BMS1P15 →	+0.065	+2.007	<.001	<.001	3	3
LUAD	TYMSP2 →	+0.146	+4.928	<.001	<.001	3	3
UCEC	PTBP1 →	+0.269	+1.658	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,904 associations by consensus.

Exploration

RGS6 survival (RNA) · tumor vs normal (RNA) · all RGS6 data types