Across TCGA patient cohorts, RGS6 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RGS6-associated genes across cancer lineages are eIF4E, MEK1, and ATM. Each is linked with RGS6 in more than 2 cancer types. Because this analysis shows association rather than direction, both RGS6-to-partner and partner-to-RGS6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGS6→partner) and Y-score (partner→RGS6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	eIF4E →	+0.151	+2.821	.035	.035	2	3
UCEC	MEK1 →	+0.455	+2.000	<.001	<.001	3	2
UCEC	ATM →	-0.462	-2.087	.001	.005	3	2
UCEC	EGFR_pY1068 →	-0.181	-1.716	.026	.003	3	1
UCEC	eIF4G →	+0.239	+2.115	.017	.016	3	1
UCEC	FoxM1 →	+0.168	+1.459	.045	.012	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Exploration

RGS6 survival (RNA) · tumor vs normal (RNA) · all RGS6 data types