Across TCGA cell cohorts, RGS6 mutation is significantly associated with the RNA expression of many other genes, with 50 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RGS6-associated genes across cancer lineages are C9orf92, HMX3, and GUCA1A. Each is linked with RGS6 in more than 1 cancer types. Because this analysis shows association rather than direction, both RGS6-to-partner and partner-to-RGS6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGS6→partner) and Y-score (partner→RGS6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	C9orf92 →	+0.194	+5.369	<.001	.004	3	1
LARGE_INTESTINE	HMX3 →	+0.785	+3.794	<.001	.001	3	1
LARGE_INTESTINE	GUCA1A →	+0.039	+2.841	.002	.009	3	1
CNS	UGT2B10 →	+0.039	+4.321	<.001	.009	3	1
CNS	SMR3B →	+0.592	+4.472	.008	.004	3	1
CNS	MC2R →	+0.004	+4.754	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

Exploration

RGS6 survival (RNA) · tumor vs normal (RNA) · all RGS6 data types