Across TCGA cell cohorts, RGS6 mutation is significantly associated with the mutation status of many other genes, with 4,739 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RGS6-associated genes across cancer lineages are TELO2, ZNF536, and PLXNA4. Each is linked with RGS6 in more than 4 cancer types. Because this analysis shows association rather than direction, both RGS6-to-partner and partner-to-RGS6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGS6→partner) and Y-score (partner→RGS6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TELO2 →	+5.303	+4.339	<.001	<.001	1	5
UPPER_AERODIGESTIVE_TRACT	ZNF536 →	+3.193	+3.660	.006	.006	1	5
UPPER_AERODIGESTIVE_TRACT	PLXNA4 →	+4.193	+4.193	.002	.002	1	5
BLOOD_Leukemia	RLF →	+3.635	+3.635	.003	.003	1	5
CNS	BCL11B →	+3.877	+5.139	.001	.001	1	5
BLOOD_Leukemia	CLUH →	+3.243	+3.762	.001	.001	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,739 associations by consensus.

Exploration

RGS6 survival (RNA) · tumor vs normal (RNA) · all RGS6 data types