RGS5-AS1

Across TCGA pan-cancer cohorts, RGS5-AS1 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated RGS5-AS1 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher RGS5-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RGS5-AS1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and CESC show a favorable association.

UVM, KIRC, and CESC are the cancer types where RGS5-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	All	0.580	0.888	<.001	45	view →
KIRC	OS	Tertile	All	0.916	0.848	.002	35	view →
CESC	DFS	Tertile	III,IV	0.872	0.312	.025	30	view →
ACC	DFS	Quartile	III,IV	0.300	0.686	<.001	27	view →
BRCA	DFS	Tertile	All	0.867	0.909	.007	20	view →
LUSC	OS	Tertile	IV	0.001	0.651	.025	18	view →
LUAD	DFS	Tertile	II,III,IV	0.655	0.347	.009	18	view →
THCA	DFS	Tertile	IV	1.000	0.603	.012	17	view →
DLBC	DFS	Quartile	II,III,IV	0.396	0.853	.033	12	view →
COAD	OS	Tertile	IV	0.401	0.710	.013	9	view →
THYM	DFS	Tertile	All	0.968	0.700	.024	8	view →
MESO	OS	Tertile	IV	0.889	0.459	.048	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

RGS5-AS1–UVM (OS)

Open the UVM breakdown →