RGS4

Across TCGA patient cohorts, RGS4 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RGS4-associated genes across cancer lineages are PCNA, AMPK_pT172, and C-Raf. Each is linked with RGS4 in more than 1 cancer types. Because this analysis shows association rather than direction, both RGS4-to-partner and partner-to-RGS4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by RGS4-low versus RGS4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGS4→partner) and Y-score (partner→RGS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.186	+3.169	.019	.018	3	2
UCEC	AMPK_pT172 →	+0.322	+2.321	.033	.034	3	2
UCEC	C-Raf →	+0.212	+3.906	<.001	<.001	3	2
UCEC	EGFR_pY1068 →	-0.302	-2.247	.001	.001	3	1
UCEC	eIF4E →	+0.157	+2.222	.042	.010	3	1
UCEC	A-Raf_pS299 →	-0.182	-2.736	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

PCNA by RGS4 expression — UCEC

Explore this box plot interactively →