RGS4

Across TCGA cell cohorts, RGS4 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,730 significant associations in total. CNS shows the largest number of these associations.

The most reproducible RGS4-associated GO terms across cancer lineages are Negative regulation of receptor signaling pathway via JAK-STAT, Negative regulation of dopamine receptor signaling pathway, and Negative regulation of receptor signaling pathway via STAT. Each is linked with RGS4 in more than 9 cancer types. Because this analysis shows association rather than direction, both RGS4-to-partner and partner-to-RGS4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of receptor signaling pathway via JAK-STAT grouped by RGS4-low versus RGS4-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RGS4→partner) and Y-score (partner→RGS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Negative regulation of receptor signaling pathway via JAK-STAT →	+0.085	+1.690	<.001	.002	3	10
LUNG_NSCLC_LUSC	Negative regulation of dopamine receptor signaling pathway →	+1.772	+4.401	<.001	.003	3	9
SKIN	Negative regulation of receptor signaling pathway via STAT →	+0.083	+1.758	<.001	.001	3	9
BONE	PML body organization →	+0.200	+2.723	<.001	.004	2	9
CNS	Positive regulation of stress fiber assembly →	+0.103	+2.228	<.001	.004	3	8
SKIN	Morphogenesis of an epithelial fold →	-1.080	-1.777	<.001	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,730 associations by consensus.

Negative regulation of receptor signaling pathway via JAK-STAT by RGS4 expression — SKIN

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