RGS4

Across TCGA cell cohorts, RGS4 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible RGS4-associated genes across cancer lineages are KLHL40, CST9, and MRGPRG. Each is linked with RGS4 in more than 1 cancer types. Because this analysis shows association rather than direction, both RGS4-to-partner and partner-to-RGS4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLHL40 grouped by RGS4-low versus RGS4-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGS4→partner) and Y-score (partner→RGS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KLHL40 →	+0.013	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	CST9 →	+0.119	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	MRGPRG →	+0.056	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	SPATA8 →	+0.217	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	OR2T4 →	+0.022	+5.209	<.001	.005	3	1
LARGE_INTESTINE	TECRL →	+0.026	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

KLHL40 by RGS4 expression — BLOOD_Lymphoma

Explore this box plot interactively →