RGS22

Across TCGA patient cohorts, RGS22 mutation is significantly associated with the total protein of many other genes, with 70 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RGS22-associated genes across cancer lineages are 4E-BP1, Acetyl-a-Tubulin-Lys40, and ASNS. Each is linked with RGS22 in more than 2 cancer types. Because this analysis shows association rather than direction, both RGS22-to-partner and partner-to-RGS22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by RGS22-low versus RGS22-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGS22→partner) and Y-score (partner→RGS22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.286	+3.087	<.001	<.001	3	3
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.344	+1.398	.017	.004	3	3
UCEC	ASNS →	+0.402	+1.925	<.001	.004	3	3
UCEC	Cyclin-E2 →	+0.099	+1.584	.038	.001	3	3
LUAD	IRS1 →	+0.139	+3.169	.037	.019	2	3
COAD	Smad4 →	+0.118	+3.169	.040	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 70 associations by consensus.

4E-BP1 by RGS22 expression — UCEC

Explore this box plot interactively →