RGS22

Across TCGA cell cohorts, RGS22 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,083 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible RGS22-associated GO terms across cancer lineages are Positive regulation of protein modification by small protein conjugation or removal, Proton motive force-driven mitochondrial ATP synthesis, and Protein K48-linked ubiquitination. Each is linked with RGS22 in more than 4 cancer types. Because this analysis shows association rather than direction, both RGS22-to-partner and partner-to-RGS22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of protein modification by small protein conjugation or removal grouped by RGS22-low versus RGS22-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RGS22→partner) and Y-score (partner→RGS22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Positive regulation of protein modification by small protein conjugation or removal →	+0.047	+0.756	.008	.002	3	5
BLOOD_Lymphoma	Proton motive force-driven mitochondrial ATP synthesis →	+0.066	+0.085	.003	.008	3	5
BLOOD_Lymphoma	Protein K48-linked ubiquitination →	+0.024	+0.051	.009	.005	3	5
CNS	Regulation of post-translational protein modification →	+0.041	+0.180	<.001	.008	3	5
CNS	Regulation of protein modification by small protein conjugation or removal →	+0.040	+0.110	<.001	.003	3	5
BLOOD_Leukemia	Regulation of collagen metabolic process →	-0.059	-0.068	.005	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,083 associations by consensus.

Positive regulation of protein modification by small protein conjugation or removal by RGS22 expression — LUNG_SCLC

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