RGS22

Across TCGA cell cohorts, RGS22 mutation is significantly associated with the RNA expression of many other genes, with 133 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RGS22-associated genes across cancer lineages are WFDC11, H2BC1, and H2AC1. Each is linked with RGS22 in more than 1 cancer types. Because this analysis shows association rather than direction, both RGS22-to-partner and partner-to-RGS22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WFDC11 grouped by RGS22-low versus RGS22-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGS22→partner) and Y-score (partner→RGS22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	WFDC11 →	+0.053	+4.643	<.001	.008	3	1
SOFT_TISSUE	H2BC1 →	+0.433	+5.977	<.001	.001	3	1
SOFT_TISSUE	H2AC1 →	+0.193	+5.977	<.001	.001	3	1
SOFT_TISSUE	OR2M2 →	+0.018	+4.930	<.001	.008	3	1
SOFT_TISSUE	KRTAP10-1 →	+0.034	+5.369	.002	.004	3	1
SOFT_TISSUE	GAGE12E →	+0.090	+4.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 133 associations by consensus.

WFDC11 by RGS22 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →