RGS19

Across TCGA patient cohorts, RGS19 mutation is significantly associated with the RNA expression of many other genes, with 136 significant associations in total. COAD shows the largest number of these associations.

The most reproducible RGS19-associated genes across cancer lineages are MIR16-1, RNA5SP319, and RNU6-601P. Each is linked with RGS19 in more than 1 cancer types. Because this analysis shows association rather than direction, both RGS19-to-partner and partner-to-RGS19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR16-1 grouped by RGS19-low versus RGS19-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGS19→partner) and Y-score (partner→RGS19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	MIR16-1 →	+0.422	+7.307	<.001	<.001	3	2
COAD	RNA5SP319 →	+0.559	+4.686	<.001	<.001	3	2
COAD	RNU6-601P →	+0.480	+4.251	<.001	.008	3	2
COAD	MIR596 →	+0.753	+3.776	.007	.006	3	2
COAD	DNM1P38 →	+0.264	+3.652	.002	.003	3	2
COAD	RBPJP2 →	+0.032	+5.142	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 136 associations by consensus.

MIR16-1 by RGS19 expression — BLCA

Explore this box plot interactively →