RGS19

Across TCGA cell cohorts, RGS19 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,937 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RGS19-associated GO terms across cancer lineages are Negative regulation of t-circle formation, Pyrimidine nucleoside biosynthetic process, and Transcription initiation at RNA polymerase II promoter. Each is linked with RGS19 in more than 11 cancer types. Because this analysis shows association rather than direction, both RGS19-to-partner and partner-to-RGS19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of t-circle formation grouped by RGS19-low versus RGS19-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RGS19→partner) and Y-score (partner→RGS19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Negative regulation of t-circle formation →	+0.130	+1.636	<.001	<.001	3	12
BONE	Pyrimidine nucleoside biosynthetic process →	+0.152	+1.032	<.001	<.001	3	11
STOMACH	Transcription initiation at RNA polymerase II promoter →	+0.064	+1.278	<.001	<.001	3	11
SOFT_TISSUE	Negative regulation of MyD88-dependent toll-like receptor signaling pathway →	+0.093	+0.776	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	DNA-templated transcription initiation →	+0.071	+1.020	.003	<.001	3	10
BONE	DNA replication proofreading →	+0.230	+1.246	.002	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,937 associations by consensus.

Negative regulation of t-circle formation by RGS19 expression — LARGE_INTESTINE

Explore this box plot interactively →