RGS17

Across TCGA patient cohorts, RGS17 mutation is significantly associated with the RNA expression of many other genes, with 1,107 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RGS17-associated genes across cancer lineages are MRPL49P2, TRBV24OR9-2, and EIF4BP4. Each is linked with RGS17 in more than 1 cancer types. Because this analysis shows association rather than direction, both RGS17-to-partner and partner-to-RGS17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPL49P2 grouped by RGS17-low versus RGS17-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGS17→partner) and Y-score (partner→RGS17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MRPL49P2 →	+0.072	+6.342	<.001	.001	3	2
HNSC	TRBV24OR9-2 →	+0.092	+5.736	.004	.003	3	2
CESC	EIF4BP4 →	+0.028	+5.418	<.001	.005	3	2
UCEC	MIR7976 →	+0.344	+2.131	<.001	.005	3	2
SKCM	MIR8076 →	+0.499	+5.436	<.001	.005	3	1
UCEC	MIR4672 →	+0.451	+2.211	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,107 associations by consensus.

MRPL49P2 by RGS17 expression — CESC

Explore this box plot interactively →