RGS16

Across TCGA patient cohorts, RGS16 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RGS16-associated genes across cancer lineages are 14-3-3_beta, p90 RSK, and Shc_pY317. Each is linked with RGS16 in more than 1 cancer types. Because this analysis shows association rather than direction, both RGS16-to-partner and partner-to-RGS16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by RGS16-low versus RGS16-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGS16→partner) and Y-score (partner→RGS16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.141	-2.986	.015	.037	3	1
UCEC	p90 RSK →	+0.236	+3.013	.033	.019	3	1
UCEC	Shc_pY317 →	-0.306	-2.999	<.001	.035	3	1
UCEC	STAT3_pY705 →	-0.451	-2.990	.002	.036	3	1
UCEC	CD31 →	-0.179	-3.000	.035	.037	3	1
UCEC	Cyclin-E2 →	+0.261	+2.817	.007	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

14-3-3_beta by RGS16 expression — UCEC

Explore this box plot interactively →