RGS13

Across TCGA patient cohorts, RGS13 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RGS13-associated genes across cancer lineages are Caspase-7-cleavedD198, PCNA, and Rad50. Each is linked with RGS13 in more than 1 cancer types. Because this analysis shows association rather than direction, both RGS13-to-partner and partner-to-RGS13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by RGS13-low versus RGS13-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGS13→partner) and Y-score (partner→RGS13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.731	+2.827	.024	.035	3	1
UCEC	PCNA →	+0.318	+3.169	.007	.020	1	1
UCEC	Rad50 →	-0.339	-3.169	.010	.020	1	1
UCEC	SCD →	+0.144	+3.183	.017	.010	1	1
UCEC	c-Jun_pS73 →	-0.190	-3.169	.029	.020	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Caspase-7-cleavedD198 by RGS13 expression — UCEC

Explore this box plot interactively →