RGS10

Across TCGA patient cohorts, RGS10 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RGS10-associated genes across cancer lineages are GAPDH, PCNA, and N-Ras. Each is linked with RGS10 in more than 1 cancer types. Because this analysis shows association rather than direction, both RGS10-to-partner and partner-to-RGS10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by RGS10-low versus RGS10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGS10→partner) and Y-score (partner→RGS10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.781	+3.000	.011	.037	3	2
UCEC	PCNA →	+0.314	+3.000	.011	.037	3	2
UCEC	N-Ras →	-0.139	-2.986	.043	.037	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.588	-2.986	.023	.037	3	1
UCEC	PKC-b-II_pS660 →	-0.343	-3.000	.031	.037	3	1
UCEC	Bax →	+0.419	+3.000	.002	.037	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

GAPDH by RGS10 expression — UCEC

Explore this box plot interactively →