RGS10

Across TCGA cell cohorts, RGS10 protein abundance is significantly associated with the go_rna of many other GO terms, with 2,516 significant associations in total. BONE shows the largest number of these associations.

The most reproducible RGS10-associated GO terms across cancer lineages are Negative regulation of response to endoplasmic reticulum stress, Negative regulation of leukocyte activation, and Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. Each is linked with RGS10 in more than 6 cancer types. Because this analysis shows association rather than direction, both RGS10-to-partner and partner-to-RGS10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of response to endoplasmic reticulum stress grouped by RGS10-low versus RGS10-high in BONE.

protein abundance associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RGS10→partner) and Y-score (partner→RGS10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of response to endoplasmic reticulum stress →	+0.132	+1.316	.009	.004	3	7
OVARY	Negative regulation of leukocyte activation →	+0.076	+0.909	<.001	.001	3	6
BONE	Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway →	+0.163	+1.552	.008	.005	3	5
LUNG_SCLC	Protein exit from endoplasmic reticulum →	+0.135	+1.061	.007	<.001	2	6
CNS	Protein N-linked glycosylation →	+0.073	+1.447	<.001	.009	3	5
BLOOD_Lymphoma	Cell cycle DNA replication initiation →	-0.170	-1.655	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,516 associations by consensus.

Negative regulation of response to endoplasmic reticulum stress by RGS10 expression — BONE

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