RGR

Across TCGA pan-cancer cohorts, RGR Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RGR data layer compared with 24 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher RGR Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated RGR expression acts as an unfavorable survival marker.

THYM, CESC, and COAD are the cancer types where RGR Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	All	0.604	0.975	<.001	36	view →
CESC	OS	Median	All	0.400	0.878	<.001	24	view →
COAD	OS	Median	All	0.168	0.806	.002	18	view →
SKCM	OS	Median	III,IV	0.216	0.807	<.001	14	view →
BLCA	OS	Median	IV	0.193	0.598	.047	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RGR–THYM (OS)

Open the THYM breakdown →