RGR

Across TCGA patient cohorts, RGR mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RGR-associated genes across cancer lineages are Annexin-1, ATM, and mTOR_pS2448. Each is linked with RGR in more than 1 cancer types. Because this analysis shows association rather than direction, both RGR-to-partner and partner-to-RGR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by RGR-low versus RGR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGR→partner) and Y-score (partner→RGR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.494	+2.827	.037	.035	3	2
UCEC	ATM →	-0.806	-3.169	<.001	.019	3	2
UCEC	mTOR_pS2448 →	-0.143	-2.000	.033	.032	3	1
UCEC	Notch1 →	+0.260	+3.472	<.001	.002	3	1
UCEC	p62 Lck ligand →	+0.299	+2.000	.041	.032	3	1
UCEC	PDCD4 →	-0.625	-3.169	.003	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Annexin-1 by RGR expression — UCEC

Explore this box plot interactively →