RGR

Across TCGA cell cohorts, RGR mutation is significantly associated with the mutation status of many other genes, with 68 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RGR-associated genes across cancer lineages are CES3, GHRHR, and CSPP1. Each is linked with RGR in more than 1 cancer types. Because this analysis shows association rather than direction, both RGR-to-partner and partner-to-RGR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CES3 grouped by RGR-low versus RGR-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGR→partner) and Y-score (partner→RGR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CES3 →	+4.000	+5.050	.008	.008	1	2
STOMACH	GHRHR →	+4.807	+4.807	.008	.008	1	2
BLOOD_Leukemia	CSPP1 →	+4.000	+5.050	.008	.008	1	1
BLOOD_Leukemia	RBM28 →	+4.321	+5.285	.005	.005	1	1
BLOOD_Leukemia	DKK1 →	+6.321	+6.321	.001	.001	1	1
BLOOD_Leukemia	RASAL1 →	+4.000	+5.050	.008	.008	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 68 associations by consensus.

CES3 by RGR expression — BLOOD_Leukemia

Explore this box plot interactively →