RGPD6

Across TCGA pan-cancer cohorts, RGPD6 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of RGPD6’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RGPD6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RGPD6 is over-expressed in tumor, although a few such as LUAD show the opposite, repressed pattern.

HNSC, LUAD, and KIRP are the cancer types where RGPD6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RGPD6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.005	<.001	9	view →
LUAD	All	All	−0.004	.019	3	view →
KIRP	Female	II,III,IV	+0.010	.020	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

RGPD6–HNSC

Open the HNSC breakdown →