Across TCGA pan-cancer cohorts, RGPD4 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of RGPD4’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where RGPD4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RGPD4 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.
BRCA, HNSC, and THCA are the cancer types where RGPD4 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RGPD4 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.