RGPD3

Across TCGA patient cohorts, RGPD3 mutation is significantly associated with the RNA expression of many other genes, with 6,460 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RGPD3-associated genes across cancer lineages are ABRAXAS2, UMAD1, and AATF. Each is linked with RGPD3 in more than 3 cancer types. Because this analysis shows association rather than direction, both RGPD3-to-partner and partner-to-RGPD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ABRAXAS2 grouped by RGPD3-low versus RGPD3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGPD3→partner) and Y-score (partner→RGPD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ABRAXAS2 →	+0.295	+1.389	.001	<.001	3	4
UCEC	UMAD1 →	+0.283	+1.576	.005	.003	3	4
UCEC	AATF →	+0.299	+1.657	.001	<.001	3	3
LUAD	THOC5 →	+0.616	+3.193	<.001	.009	3	3
UCEC	SLC7A1 →	+0.814	+1.818	<.001	<.001	3	3
LUAD	RN7SKP192 →	+0.045	+3.046	.003	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,460 associations by consensus.

ABRAXAS2 by RGPD3 expression — UCEC

Explore this box plot interactively →