RGMB

Across TCGA patient cohorts, RGMB mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RGMB-associated genes across cancer lineages are MAPK_pT202_Y204, N-Cadherin, and PCNA. Each is linked with RGMB in more than 1 cancer types. Because this analysis shows association rather than direction, both RGMB-to-partner and partner-to-RGMB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAPK_pT202_Y204 grouped by RGMB-low versus RGMB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGMB→partner) and Y-score (partner→RGMB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MAPK_pT202_Y204 →	-0.461	-2.000	.029	.032	3	1
UCEC	N-Cadherin →	+0.216	+2.331	.023	.019	3	1
UCEC	PCNA →	+0.196	+2.700	.044	.006	3	1
UCEC	Caspase-7-cleavedD198 →	+0.733	+2.000	.006	.032	3	1
UCEC	CD20 →	+0.131	+2.189	.027	.034	3	1
UCEC	p62 Lck ligand →	+0.397	+3.009	.006	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

MAPK_pT202_Y204 by RGMB expression — UCEC

Explore this box plot interactively →