RGMB

Across TCGA cell cohorts, RGMB mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RGMB-associated genes across cancer lineages are KRTAP21-2, KRTAP12-1, and KRTAP22-2. Each is linked with RGMB in more than 1 cancer types. Because this analysis shows association rather than direction, both RGMB-to-partner and partner-to-RGMB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP21-2 grouped by RGMB-low versus RGMB-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGMB→partner) and Y-score (partner→RGMB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KRTAP21-2 →	+0.062	+4.539	.001	.007	3	2
BLOOD_Myeloma	KRTAP12-1 →	+0.066	+4.807	<.001	.006	3	1
BLOOD_Myeloma	KRTAP22-2 →	+0.229	+4.807	<.001	.006	3	1
BLOOD_Myeloma	KIR2DS4 →	+0.023	+4.807	<.001	.006	3	1
BLOOD_Leukemia	OR10T2 →	+0.595	+4.276	.004	.007	3	1
BLOOD_Leukemia	FAM24A →	+0.061	+4.969	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

KRTAP21-2 by RGMB expression — BLOOD_Leukemia

Explore this box plot interactively →