RGMA

Across TCGA pan-cancer cohorts, RGMA Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated RGMA data layer compared with 22 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher RGMA Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated RGMA expression acts as an unfavorable survival marker, although some lineages such as BLCA show a favorable association.

ESCA, READ, and BRCA are the cancer types where RGMA Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	III,IV	0.160	0.582	<.001	18	view →
READ	OS	Median	II,III,IV	0.287	0.816	.001	15	view →
BRCA	OS	Median	All	0.107	0.578	<.001	12	view →
BLCA	DFS	Median	All	1.000	0.323	.017	11	view →
SARC	DFS	Median	All	0.117	0.635	.001	9	view →
STAD	OS	Median	All	0.250	0.729	.028	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
LIHC	OS	Median	All	0.105	0.774	.002	3	view →
COAD	DFS	Median	All	0.311	0.693	.046	3	view →
SKCM	OS	Median	III,IV	0.179	0.721	<.001	3	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

RGMA–ESCA (OS)

Open the ESCA breakdown →