Across TCGA pan-cancer cohorts, RGL3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RGL3 data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher RGL3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated RGL3 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

UCEC, LUAD, and CCRCC are the cancer types where RGL3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	III,IV	0.311	1.000	.001	20	view →
LUAD	OS	Median	All	0.533	0.903	.002	13	view →
CCRCC	OS	Tertile	IV	0.961	0.199	.036	7	view →
PDAC	OS	Median	All	0.350	0.760	.042	4	view →
LSCC	DFS	Median	II,III,IV	0.549	1.000	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: RGL3 tumor-vs-normal RNA expression · all RGL3 data types