Across TCGA patient cohorts, RGL3 mutation is significantly associated with the RNA expression of many other genes, with 1,606 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RGL3-associated genes across cancer lineages are NDUFA9, DDB2, and HNRNPL. Each is linked with RGL3 in more than 2 cancer types. Because this analysis shows association rather than direction, both RGL3-to-partner and partner-to-RGL3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGL3→partner) and Y-score (partner→RGL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	NDUFA9 →	+0.329	+3.410	.001	.004	3	3
UCEC	DDB2 →	+0.659	+3.906	<.001	<.001	3	3
SKCM	HNRNPL →	+0.288	+3.488	.003	.002	3	2
SKCM	CGB3 →	+0.226	+2.341	<.001	.003	3	2
SKCM	GPI →	+0.515	+2.709	.003	.003	3	2
SKCM	MFSD13A →	+0.570	+3.019	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,606 associations by consensus.

Exploration

RGL3 survival (RNA) · tumor vs normal (RNA) · all RGL3 data types