RGL3

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RGL3 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RGL3-associated genes across cancer lineages are PCNA, FOXO3a_pS318_S321, and A-Raf_pS299. Each is linked with RGL3 in more than 2 cancer types. Because this analysis shows association rather than direction, both RGL3-to-partner and partner-to-RGL3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGL3→partner) and Y-score (partner→RGL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECPCNA →+0.193+1.584.011.03433
SKCMFOXO3a_pS318_S321 →-0.138-2.982.041.03433
SKCMA-Raf_pS299 →-0.178-2.321.012.03532
UCECp90 RSK_pT359_S363 →-0.168-1.874.018.04932
UCECTFRC →+0.396+1.874.034.04932
SKCMTIGAR →+0.160+3.012.012.01832
Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

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