RGL2

Across TCGA patient cohorts, RGL2 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RGL2-associated genes across cancer lineages are Notch1, MEK1, and N-Ras. Each is linked with RGL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both RGL2-to-partner and partner-to-RGL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by RGL2-low versus RGL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGL2→partner) and Y-score (partner→RGL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.151	+1.713	.001	.024	3	3
UCEC	MEK1 →	+0.402	+2.736	.001	<.001	3	2
UCEC	N-Ras →	-0.104	-1.680	.011	.042	3	2
UCEC	Rictor_pT1135 →	-0.108	-2.807	.002	.002	3	2
UCEC	Caspase-7-cleavedD198 →	+0.715	+2.019	<.001	.005	3	2
UCEC	4E-BP1 →	+0.322	+2.444	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Notch1 by RGL2 expression — UCEC

Explore this box plot interactively →