RGL1

Across TCGA patient cohorts, RGL1 mutation is significantly associated with the RNA expression of many other genes, with 3,578 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RGL1-associated genes across cancer lineages are RNU6-160P, RNA5SP411, and CENPU. Each is linked with RGL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both RGL1-to-partner and partner-to-RGL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-160P grouped by RGL1-low versus RGL1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGL1→partner) and Y-score (partner→RGL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-160P →	+0.737	+4.478	<.001	.002	3	3
UCEC	RNA5SP411 →	+0.863	+1.600	<.001	<.001	3	3
UCEC	CENPU →	+0.567	+2.364	<.001	<.001	3	3
UCEC	SKA1 →	+0.629	+1.642	<.001	<.001	3	3
UCEC	CHAF1B →	+0.478	+1.632	<.001	<.001	3	3
SKCM	POC1A →	+0.449	+3.510	.006	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,578 associations by consensus.

RNU6-160P by RGL1 expression — BLCA

Explore this box plot interactively →