RGL1

Across TCGA patient cohorts, RGL1 mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RGL1-associated genes across cancer lineages are Src_pY527, p90 RSK, and Snail. Each is linked with RGL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both RGL1-to-partner and partner-to-RGL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Src_pY527 grouped by RGL1-low versus RGL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGL1→partner) and Y-score (partner→RGL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Src_pY527 →	-0.303	-1.668	.021	.021	3	3
SKCM	p90 RSK →	+0.223	+2.584	.011	.010	3	2
UCEC	Snail →	-0.193	-1.999	.049	.008	3	2
UCEC	eIF4E →	+0.134	+2.247	.038	.001	3	2
UCEC	ERK2 →	+0.207	+2.087	<.001	.004	3	2
UCEC	GAPDH →	+0.339	+2.115	.039	.016	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

Src_pY527 by RGL1 expression — UCEC

Explore this box plot interactively →