RGL1

Across TCGA cell cohorts, RGL1 mutation is significantly associated with the RNA expression of many other genes, with 1,204 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RGL1-associated genes across cancer lineages are GZMK, F11, and VWC2L. Each is linked with RGL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RGL1-to-partner and partner-to-RGL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GZMK grouped by RGL1-low versus RGL1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RGL1→partner) and Y-score (partner→RGL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GZMK →	+0.855	+4.037	<.001	.004	3	2
BLOOD_Leukemia	F11 →	+0.105	+3.855	<.001	.007	3	2
BLOOD_Leukemia	VWC2L →	+0.012	+4.339	<.001	.002	3	2
BLOOD_Myeloma	CD164L2 →	+0.035	+3.285	.003	.009	3	1
BLOOD_Myeloma	SCYGR10 →	+0.223	+4.321	<.001	<.001	3	1
OVARY	MC3R →	+0.050	+4.700	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,204 associations by consensus.

GZMK by RGL1 expression — BLOOD_Leukemia

Explore this box plot interactively →