RGCC

Across TCGA pan-cancer cohorts, RGCC mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated RGCC data layer compared with 27 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher RGCC mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated RGCC expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

CCRCC, LUAD, and PDAC are the cancer types where RGCC mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	III,IV	0.778	0.467	.022	17	view →
LUAD	OS	Tertile	II,III,IV	0.850	0.489	.004	16	view →
PDAC	DFS	Median	IV	0.267	0.749	.038	6	view →
HNSC	DFS	Median	IV	0.889	0.407	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

RGCC–CCRCC (DFS)

Open the CCRCC breakdown →