RFXAP

Across TCGA pan-cancer cohorts, RFXAP RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of RFXAP’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where RFXAP RNA is repressed in tumor relative to normal tissue. In most cancer types RFXAP is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and LUAD are the cancer types where RFXAP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RFXAP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	IV	−1.155	<.001	11	view →
KICH	Female	II,III,IV	−1.301	<.001	10	view →
LUAD	All	III,IV	−0.718	<.001	9	view →
COAD	Female	II,III,IV	+0.936	<.001	8	view →
LUSC	All	II,III,IV	−0.537	<.001	7	view →
BRCA	All	All	−0.602	<.001	6	view →
LIHC	All	All	+0.347	<.001	6	view →
CHOL	All	All	+1.275	<.001	5	view →
UCEC	All	All	−0.651	.001	4	view →
HNSC	All	III,IV	+0.368	.015	3	view →
BLCA	Male	IV	−0.912	.010	2	view →
KIRP	All	All	−0.383	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

RFXAP–THCA

Open the THCA breakdown →