RFX8

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RFX8 mutation is significantly associated with the RNA expression of many other genes, with 2,556 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RFX8-associated genes across cancer lineages are RBAK-RBAKDN, SSXP9, and SSRP1. Each is linked with RFX8 in more than 1 cancer types. Because this analysis shows association rather than direction, both RFX8-to-partner and partner-to-RFX8 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFX8→partner) and Y-score (partner→RFX8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECRBAK-RBAKDN →+0.098+2.575<.001<.00132
CESCSSXP9 →+0.148+5.969<.001.00232
UCECSSRP1 →+0.607+3.021.001<.00132
UCECRMND1 →+0.792+3.742<.001<.00132
UCECCHAF1B →+0.700+3.716<.001<.00132
UCECTYW3 →+0.536+3.502<.001.00232
Each partner links to its Q-omics profile. Showing the 6 strongest of 2,556 associations by consensus.

Exploration