RFX8

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RFX8 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RFX8-associated genes across cancer lineages are JNK_pT183_Y185, Annexin-1, and ASNS. Each is linked with RFX8 in more than 1 cancer types. Because this analysis shows association rather than direction, both RFX8-to-partner and partner-to-RFX8 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFX8→partner) and Y-score (partner→RFX8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECJNK_pT183_Y185 →-0.194-3.459.005.00532
UCECAnnexin-1 →+0.566+2.341.009.01932
UCECASNS →+0.380+3.169.010.01832
UCECATM →-0.370-2.321.048.00632
UCEC14-3-3_beta →-0.108-3.439.009.00531
UCECEGFR_pY1068 →-0.315-3.000.002.00131
Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Exploration